Article
Co-existence of BRAF V600E Gene Mutation in Tumor and Non-tumoral Surrounding Tissues in Colorectal Cancer.
In vivo (Athens, Greece) - 1 Jan 2000
Öztürk Tülin, Toptaş-Hekimoğlu Bahar, Eronat Allison Pinar, Saygili Neslihan, Dağlar-Aday Aynur, Başsüllü Nuray, Türkmen Ilknur, Aydoğan Hülya Yilmaz, Bülbül Gülen, Göksel Süha, Öztürk Oğuz, Isbir Turgay
Abstract excerpt
BACKGROUND/AIM: The murine sarcoma viral (V-Raf) oncogene homolog B (BRAF) V600E mutation, which increases protein kinase activity in BRAF-mitogen-activated protein kinase kinase (MEK) - extracellular signal-regulated kinases (ERK) (mitogen-activated protein kinase (MAPK)) signaling, is found in 5-40% of all colorectal carcinoma cases. Proteins with this mutation are reported to be 130-fold more active, which...
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