Clinical meaning of BRAF mutation in Korean patients with advanced colorectal cancer.

doi:10.3748/wjg.v20.i15.4370

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Article

Clinical meaning of BRAF mutation in Korean patients with advanced colorectal cancer.

World journal of gastroenterology - 21 Apr 2014

Kim Bun, Park Soo Jung, Cheon Jae Hee, Kim Tae Il, Kim Won Ho, Hong Sung Pil

Abstract excerpt

AIM: To evaluate the clinicopathological features of colorectal cancer (CRC) with a v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation and its molecular interaction with microsatellite instability (MSI) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) in patients with advanced CRCs. METHODS: From October 2009 to December 2011, 141 patients with stage III (n = 51) or IV (n = 90) CRCs who...

Topics

Aged
Biomarkers, Tumor
Colorectal Neoplasms
DNA Mutational Analysis
Disease-Free Survival
Female
Humans
Male
Microsatellite Instability
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

Proto-Oncogene Proteins

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Republic of Korea

Treatment Outcome

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24764675
DOI: 10.3748/wjg.v20.i15.4370
PMCID: PMC3989973

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24764675-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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