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Article

A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,2

14 May 2014

Abstract excerpt

CXCL12-CXCR4-CXCR7 signaling promotes tumor growth and metastasis in breast cancer. Alternative splicing of CXCL12 produces isoforms with distinct structural and biochemical properties, but little is known about isoform-specific differences in breast cancer subtypes and patient outcomes. We investigated global expression profiles of the six CXCL12 isoforms, CXCR4, and CXCR7 in The Cancer Genome Atlas breast...

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PMID: 24836649
DOI: 10.1016/j.tranon.2014.04.001

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