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Inflammatory bowel disease (IBD) locus 12: is glutathione peroxidase-1 (GPX1) the relevant gene?

Genes and immunity - 1 Dec 2015

Häuser F, Rossmann H, Laubert-Reh D, Wild P S, Zeller T, Müller C, Neuwirth S, Blankenberg S, Lackner K J

Abstract excerpt

Genome-wide association studies have identified and repeatedly confirmed the association of rs3197999 in MST1 with inflammatory bowel disease (IBD). However, the underlying pathophysiology remains unclear. rs3197999 is a non-synonymous single-nucleotide polymorphism which modifies the function of macrophage stimulating protein-1 (MST1). We show by haplotyping that rs3197999 is in linkage disequilibrium with...

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Source

Identifiers

PMID: 26355565
DOI: 10.1038/gene.2015.35

Genes

MST1
GPX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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