Article
Paraoxonase-1 status in Crohn's disease and ulcerative colitis.
Inflammatory bowel diseases - 1 Jan 2009
Boehm Dorota, Krzystek-Korpacka Malgorzata, Neubauer Katarzyna, Matusiewicz Malgorzata, Berdowska Izabela, Zielinski Bogdan, Paradowski Leszek, Gamian Andrzej
Abstract excerpt
BACKGROUND: Paraoxonase 1 (PON1) is an extracellular enzyme, which in the gastrointestinal tract may act as a local detoxifier, antioxidant, immunomodulator, and/or quorum-quenching factor. There are no data on PON1 activity in Crohn's disease (CD). METHODS: PON1 phenotype and activity were determined spectrophotometrically in 52 subjects with CD, 67 with ulcerative colitis (UC), and 99 healthy individuals, and...
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