Article
Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells.
Oncotarget - 29 Sept 2015
El Taghdouini Adil, Sørensen Anita L, Reiner Andrew H, Coll Mar, Verhulst Stefaan, Mannaerts Inge, Øie Cristina I, Smedsrød Bård, Najimi Mustapha, Sokal Etienne, Luttun Aernout, Sancho-Bru Pau, Collas Philippe, van Grunsven Leo A
Abstract excerpt
BACKGROUND & AIMS: Liver fibrogenesis - scarring of the liver that can lead to cirrhosis and liver cancer - is characterized by hepatocyte impairment, capillarization of liver sinusoidal endothelial cells (LSECs) and hepatic stellate cell (HSC) activation. To date, the molecular determinants of a healthy human liver cell phenotype remain largely uncharacterized. Here, we assess the transcriptome and the...
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