Article
A Comprehensive Sequencing-Based Analysis of Allelic Methylation Patterns in Hemostatic Genes in Human Liver.
Thrombosis and haemostasis - 1 Feb 2020
Olsson Lindvall Martina, Davila Lopez Marcela, Klasson Sofia, Hansson Lena, Nilsson Staffan, Stanne Tara M, Jern Christina
Abstract excerpt
Characterizing the relationship between genetic, epigenetic (e.g., deoxyribonucleic acid [DNA] methylation), and transcript variation could provide insights into mechanisms regulating hemostasis and potentially identify new drug targets. Several hemostatic factors are synthesized in the liver, yet high-resolution DNA methylation data from human liver tissue is currently lacking for these genes. Single-nucleotide...
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