Article
Genetic and epigenetic regulation of gene expression in fetal and adult human livers.
BMC genomics - 4 Oct 2014
Bonder Marc Jan, Kasela Silva, Kals Mart, Tamm Riin, Lokk Kaie, Barragan Isabel, Buurman Wim A, Deelen Patrick, Greve Jan-Willem, Ivanov Maxim, Rensen Sander S, van Vliet-Ostaptchouk Jana V, Wolfs Marcel G, Fu Jingyuan, Hofker Marten H, Wijmenga Cisca, Zhernakova Alexandra, Ingelman-Sundberg Magnus, Franke Lude, Milani Lili
Abstract excerpt
BACKGROUND: The liver plays a central role in the maintenance of homeostasis and health in general. However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less is known about the epigenetic factors. RESULTS: By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers, we identified 657 differentially...
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