Article
Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome-epigenome correlation.
Epigenomics - 1 Jul 2018
Arai Eri, Miura Fumihito, Totoki Yasushi, Yamashita Satoshi, Tian Ying, Gotoh Masahiro, Ojima Hidenori, Nakagawa Hiroyuki, Takahashi Yoriko, Nakamura Hiromi, Hama Natsuko, Kato Mamoru, Kimura Hiroshi, Suzuki Yutaka, Ito Takashi, Shibata Tatsuhiro, Kanai Yae
Abstract excerpt
AIM: The aim of this study was to reveal the epigenome landscape of human normal hepatocytes. MATERIALS & METHODS: Cells purified from partial hepatectomy specimens of Japanese patients were subjected to whole-genome bisulfite sequencing using postbisulfite adaptor tagging, chromatin immunoprecipitation sequencing, RNA sequencing and whole-genome sequencing. RESULTS: CHG and CHH methylations were inversely...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.