Article
[A gain-of-function mutation in FGFR2 influences mandibular condylar development on mice].
Yi chuan = Hereditas - 1 Jun 2015
Liang Xin, Zhang Bo, Liu Ping, Weng Tu-jun, Zhang Li, He Long-zhu, Li Fang-fei, Qu Chen, Wang Ping
Abstract excerpt
The development of the skeleton is regulated by numerous signaling molecules expressed in epiphyseal cartilage controlling both chondrogenesis and osteogenesis such as fibroblast growth factor receptors (FGFRs). In order to explore the important effect of fibroblast growth factor receptor 2 (FGFR2) in the process of mandibular condylar growth, we introduced gain-of-function Fgfr2(+/S252W) mice, and investigated...
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