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Article

Soluble form of FGFR2 with S252W partially prevents craniosynostosis of the apert mouse model

21 Nov 2013

Abstract excerpt

BACKGROUND: Apert syndrome (AS) is characterized by craniosynostosis, midfacial hypoplasia, and bony syndactyly. It is an autosomal dominantly inherited disease caused by point mutations (S252W or P253R) in fibroblast growth factor receptor (FGFR) 2. These mutations cause activation of FGFR2 depending on ligand binding. Recently, an AS mouse model, Fgfr2(+/) (S252W) , showed phenotypes similar to those of AS...

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PMID: 24259495
DOI: 10.1002/dvdy.24099

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