Genetic, Genomic, and Transcriptomic Studies of Pyruvate Metabolism in Methanosarcina barkeri Fusaro.

Abstract excerpt

UNLABELLED: Pyruvate, a central intermediate in the carbon fixation pathway of methanogenic archaea, is rarely used as an energy source by these organisms. The sole exception to this rule is a genetically uncharacterized Methanosarcina barkeri mutant capable of using pyruvate as a sole energy and carbon source (the Pyr(+) phenotype). Here, we provide evidence that suggests that the Pyr(+) mutant is able to...

Topics

• Bacterial Proteins
• Gene Expression Regulation, Bacterial
• Gene Expression Regulation, Enzymologic
• Genome, Bacterial
• Methanosarcina barkeri
• Mutation
• Pyruvate Synthase
• Pyruvates
• Transcriptome