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Article

A distinct holoenzyme organization for two-subunit pyruvate carboxylase.

Nature communications - 6 Oct 2016

Choi Philip H, Jo Jeanyoung, Lin Yu-Cheng, Lin Min-Han, Chou Chi-Yuan, Dietrich Lars E P, Tong Liang

Abstract excerpt

Pyruvate carboxylase (PC) has important roles in metabolism and is crucial for virulence for some pathogenic bacteria. PC contains biotin carboxylase (BC), carboxyltransferase (CT) and biotin carboxyl carrier protein (BCCP) components. It is a single-chain enzyme in eukaryotes and most bacteria, and functions as a 500 kD homo-tetramer. In contrast, PC is a two-subunit enzyme in a collection of Gram-negative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27708276
DOI: 10.1038/ncomms12713
PMCID: PMC5059739

Genes

PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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