Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gly972Arg variant of insulin receptor substrate 1 gene and colorectal cancer risk in overweight/obese subjects.

The International journal of biological markers - 28 Feb 2016

Mahmoudi Touraj, Majidzadeh-A Keivan, Karimi Khatoon, Farahani Hamid, Dabiri Reza, Nobakht Hossein, Asadi Asadollah, Karimi Negar, Arkani Maral, Zali Mohammad Reza

Abstract excerpt

BACKGROUND: Given the major role of obesity and insulin resistance (IR) in colorectal cancer (CRC), we investigated whether genetic variants in ghrelin (GHRL), resistin (RETN) and insulin receptor substrate 1 (IRS1) were associated with CRC risk. METHODS: This study was conducted as a case-control study, and 750 subjects, including 438 controls and 312 patients with CRC, were enrolled and genotyped using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to Colorectal Neoplasms

Share to Insulin Receptor Substrate Proteins

Share to Insulin Resistance

Share to Obesity

Share to Overweight

Source

Identifiers

PMID: 26349669
DOI: 10.5301/jbm.5000159

Genes

IRS1
GHRL
RETN

Variants

rs696217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gly972Arg variant of insulin receptor substrate 1 gene and colorectal cancer risk in overweight/obese subjects.PMID 26349669Read ↗

Resistin -420C>G promoter variant and colorectal cancer risk.Semantic proximity Read ↗

An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women.Semantic proximity Read ↗

IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer.Semantic proximity Read ↗

Polymorphisms in RETN gene and susceptibility to colon cancer in Saudi patients.Semantic proximity Read ↗

Association between IRS-1 Gly972Arg polymorphism and colorectal cancer risk.Semantic proximity Read ↗

Association of resistin gene polymorphisms with insulin resistance in Egyptian obese patients.Semantic proximity Read ↗

Association between the resistin gene-420 C>G polymorphism and obesity: an updated meta-analysis.Semantic proximity Read ↗

Association of lncRNA MEG3 rs941576 polymorphism, expression profile, and its related targets with the risk of obesity-related colorectal cancer: potential clinical insights.Semantic proximity Read ↗

Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.Semantic proximity Read ↗

Association between insulin receptor substrate 1 Gly972Arg polymorphism and cancer risk.Semantic proximity Read ↗

Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and ObesitySemantic proximity Read ↗

Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.