Article
Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure.
The Biochemical journal - 1 Sept 2015
Zhang Jingqun, Zhou Qiang, Smith Chris D, Chen Haiyan, Tan Zhen, Chen Biyi, Nani Alma, Wu Guogen, Song Long-Sheng, Fill Michael, Back Thomas G, Chen S R Wayne
Abstract excerpt
Carvedilol is the current β-blocker of choice for suppressing ventricular tachyarrhythmia (VT). However, carvedilol's benefits are dose-limited, attributable to its potent β-blocking activity that can lead to bradycardia and hypotension. The clinically used carvedilol is a racemic mixture of β-blocking S-carvedilol and non-β-blocking R-carvedilol. We recently reported that novel non-β-blocking carvedilol...
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