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Article

Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling.

PloS one - 1 Jan 2015

Utsunomiya Yuri T, Ribeiro Érica S, Quintal Amanda P N, Sangalli Juliano R, Gazola Valquiria R, Paula Henrique B, Trinconi Cristiana M, Lima Valéria M F, Perri Silvia H V, Taylor Jeremy F, Schnabel Robert D, Sonstegard Tad S, Garcia José F, Nunes Cáris M

Abstract excerpt

We conducted a genome-wide scan for visceral leishmaniasis in mixed-breed dogs from a highly endemic area in Brazil using 149,648 single nucleotide polymorphism (SNP) markers genotyped in 20 cases and 28 controls. Using a mixed model approach, we found two candidate loci on canine autosomes 1 and 2. The positional association on chromosome 2 mapped to a predicted DNAse sensitive site in CD14+ monocytes that serve...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2 Receptor alpha Subunit

Share to Leishmania infantum

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Source

Open in PubMed Open full text

Identifiers

PMID: 26348501
DOI: 10.1371/journal.pone.0136749
PMCID: PMC4562658

Genes

TLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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