Acylation of salmon calcitonin modulates in vitro intestinal peptide flux through membrane permeability enhancement.

Abstract excerpt

Acylation of peptide drugs with fatty acid chains has proven beneficial for prolonging systemic circulation, as well as increasing enzymatic stability and interactions with lipid cell membranes. Thus, acylation offers several potential benefits for oral delivery of therapeutic peptides, and we hypothesize that tailoring the acylation may be used to optimize intestinal translocation. This work aims to characterize...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Density Conservation Agents
• Share to Calcitonin