Article
Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A.
Gut and liver - 1 Mar 2016
Cho Hyosun, Kang Hyojeung, Kim Chang Wook, Kim Hee Yeon, Jang Jeong Won, Yoon Seung Kew, Lee Chang Don
Abstract excerpt
BACKGROUND/AIMS: The immunoregulatory molecules programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are associated with the dysfunction of antiviral effector T-cells, which leads to T-cell exhaustion and persistent viral infection in patients with chronic hepatitis C and chronic hepatitis B. Little is known about the role of PD-1 and CTLA-4 in patients with symptomatic acute...
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