Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling.

Advances in experimental medicine and biology - 1 Jan 2014

Wheeler Jason B, Ikonomidis John S, Jones Jeffrey A

Abstract excerpt

Marfan Syndrome (MFS) and Loeys-Dietz Syndrome (LDS) represent heritable connective tissue disorders that cosegregate with a similar pattern of cardiovascular defects (thoracic aortic aneurysm, mitral valve prolapse/regurgitation, and aortic root dilatation with regurgitation). This pattern of cardiovascular defects appears to be expressed along a spectrum of severity in many heritable connective tissue disorders...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic beta-Antagonists
Share to Angiotensin II Type 1 Receptor Blockers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Aneurysm, Thoracic

Share to Aortic Valve

Share to Bicuspid Aortic Valve Disease

Share to Heart Valve Diseases

Share to Loeys-Dietz Syndrome

Share to Smad Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24443024
DOI: 10.1007/978-94-007-7893-1_8
PMCID: PMC4410689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling.PMID 24443024Read ↗

Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys–Dietz SyndromesSemantic proximity Read ↗

Cardiovascular manifestations in Marfan syndrome and related diseases; multiple genes causing similar phenotypesSemantic proximity Read ↗

TGF-β Signaling-Related Genes and Thoracic Aortic Aneurysms and DissectionsSemantic proximity Read ↗

Marfan Syndrome and Related Disorders: 25 Years of Gene Discovery.Semantic proximity Read ↗

Marfan syndrome revisited: From genetics to the clinic.Semantic proximity Read ↗

Mitral valve disease in Marfan syndrome and related disorders.Semantic proximity Read ↗

Marfan syndrome type II: there is more to Marfan syndrome than fibrillin 1.Semantic proximity Read ↗

Marfan syndrome: from gene to therapy.Semantic proximity Read ↗

Type A Aortic Dissection Caused by Loeys-Dietz Syndrome with Novel Variation.Semantic proximity Read ↗

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.Semantic proximity Read ↗

Loeys-Dietz Syndrome.Semantic proximity Read ↗

Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.