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Article

BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype.

International journal of molecular sciences - 27 Aug 2015

Zhou Xiaopeng, Tao Yiqing, Liang Chengzhen, Zhang Yujie, Li Hao, Chen Qixin

Abstract excerpt

Human mesenchymal stem cells (MSCs) have the potential to differentiate into nucleus pulposus (NP)-like cells under specific stimulatory conditions. Thus far, the effects of bone morphogenetic protein 3 (BMP3) and the cocktail effects of BMP3 and transforming growth factor (TGF)-β on MSC proliferation and differentiation remain obscure. Therefore, this study was designed to clarify these unknowns. MSCs were...

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Source

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Identifiers

PMID: 26343641
DOI: 10.3390/ijms160920344
PMCID: PMC4613207

Genes

BMP3
MSC
ACAN
COMP
KRT19
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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