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TGF-β signaling regulates differentiation of MSCs in bone metabolism: disputes among viewpoints

30 May 2024

Abstract excerpt

Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into cells of different lineages to form mesenchymal tissues, which are promising in regard to treatment for bone diseases. Their osteogenic differentiation is under the tight regulation of intrinsic and extrinsic factors. Transforming growth factor β (TGF-β) is an essential growth factor in bone metabolism, which regulates the...

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PMID: 38816830
DOI: 10.1186/s13287-024-03761-w

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