Article
RhoB determines tumor aggressiveness in a murine EGFRL858R-induced adenocarcinoma model and is a potential prognostic biomarker for Lepidic lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2014
Calvayrac Olivier, Pradines Anne, Raymond-Letron Isabelle, Rouquette Isabelle, Bousquet Emilie, Lauwers-Cances Valérie, Filleron Thomas, Cadranel Jacques, Beau-Faller Michèle, Casanova Anne, Milia Julie, Favre Gilles, Mazières Julien
Abstract excerpt
PURPOSE: A crucial event in lung adenocarcinoma progression is the switch from an aerogenous spread toward an infiltrating tumor. Loss of RhoB expression has been suggested to be critical for lung cancer invasion. Here, we tested RhoB expression as a prognostic biomarker in non-small cell lung ca...
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