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Article

Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus.

The Journal of biological chemistry - 13 Nov 2015

Bamford Natalie C, Snarr Brendan D, Gravelat Fabrice N, Little Dustin J, Lee Mark J, Zacharias Caitlin A, Chabot Josée C, Geller Alexander M, Baptista Stefanie D, Baker Perrin, Robinson Howard, Howell P Lynne, Sheppard Donald C

Abstract excerpt

Aspergillus fumigatus is the most virulent species within the Aspergillus genus and causes invasive infections with high mortality rates. The exopolysaccharide galactosaminogalactan (GAG) contributes to the virulence of A. fumigatus. A co-regulated five-gene cluster has been identified and proposed to encode the proteins required for GAG biosynthesis. One of these genes, sph3, is predicted to encode a protein...

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Identifiers

PMID: 26342082
DOI: 10.1074/jbc.M115.679050
PMCID: PMC4645995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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