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Article

Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation

6 Apr 2016

Abstract excerpt

UNLABELLED: The mold Aspergillus fumigatus causes invasive infection in immunocompromised patients. Recently, galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and N-acetylgalactosamine (GalNAc), was identified as a virulence factor required for biofilm formation. The molecular mechanisms underlying GAG biosynthesis and GAG-mediated biofilm formation were unknown. We identified a cluster of...

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PMID: 27048799
DOI: 10.1128/mbio.00252-16

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