Article
Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance.
The British journal of psychiatry : the journal of mental science - 1 Feb 2016
Li Ming, Luo Xiong-jian, Landén Mikael, Bergen Sarah E, Hultman Christina M, Li Xiao, Zhang Wen, Yao Yong-Gang, Zhang Chen, Liu Jiewei, Mattheisen Manuel, Cichon Sven, Mühleisen Thomas W, Degenhardt Franziska A, Nöthen Markus M, Schulze Thomas G, Grigoroiu-Serbanescu Maria, Li Hao, Fuller Chris K, Chen Chunhui, Dong Qi, Chen Chuansheng, Jamain Stéphane, Leboyer Marion, Bellivier Frank, Etain Bruno, Kahn Jean-Pierre, Henry Chantal, Preisig Martin, Kutalik Zoltán, Castelao Enrique, Wright Adam, Mitchell Philip B, Fullerton Janice M, Schofield Peter R, Montgomery Grant W, Medland Sarah E, Gordon Scott D, Martin Nicholas G, Rietschel Marcella, Liu Chunyu, Kleinman Joel E, Hyde Thomas M, Weinberger Daniel R, Su Bing
Abstract excerpt
BACKGROUND: Bipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain. AIMS: We sought to assess the impact of eQTL variants on bipolar disorder risk by combining data from both bipolar disorder genome-wide association studies (GWAS) and brain eQTL. METHOD: To...
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