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Article

MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway.

Oncotarget - 6 Oct 2015

Wu Geyan, Liu Aibin, Zhu Jinrong, Lei Fangyong, Wu Shu, Zhang Xin, Ye Liping, Cao Lixue, He Shanyang

Abstract excerpt

Wnt/β-catenin signaling pathway is strictly controlled by multiple negative regulators. However, how tumor cells override the negative regulatory effects to maintain constitutive activation of Wnt/β-catenin signaling, which is commonly observed in various cancers, remains puzzling. In current study, we reported that overexpression of miR-1207 in ovarian cancer activated Wnt/β-catenin signaling by directly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26337084
DOI: 10.18632/oncotarget.4921
PMCID: PMC4745698

Genes

AXIN2
SFRP1

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