Article
[Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 2006
Weniger M A, Melzner I, Menz C K, Wegener S, Bucur A J, Dorsch K, Mattfeldt T, Barth T F E, Möller P
Abstract excerpt
AIMS: Suppressors of cytokine signaling (SOCS) negatively regulate Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling involved in proliferation, survival, and apoptosis. We previously showed a loss of SOCS-1 function due to deleterious mutations in a major subset of mediastinal B-cell lymphoma (MBL). In MBL cell lines this leads to retarded JAK2 degradation and sustained...
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