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Article

FUS Interacts with HSP60 to Promote Mitochondrial Damage.

PLoS genetics - 1 Sept 2015

Deng Jianwen, Yang Mengxue, Chen Yanbo, Chen Xiaoping, Liu Jianghong, Sun Shufeng, Cheng Haipeng, Li Yang, Bigio Eileen H, Mesulam Marsel, Xu Qi, Du Sidan, Fushimi Kazuo, Zhu Li, Wu Jane Y

Abstract excerpt

FUS-proteinopathies, a group of heterogeneous disorders including ALS-FUS and FTLD-FUS, are characterized by the formation of inclusion bodies containing the nuclear protein FUS in the affected patients. However, the underlying molecular and cellular defects remain unclear. Here we provide evidence for mitochondrial localization of FUS and its induction of mitochondrial damage. Remarkably, FTLD-FUS brain samples...

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Identifiers

PMID: 26335776
DOI: 10.1371/journal.pgen.1005357
PMCID: PMC4559378

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FUS Interacts with HSP60 to Promote Mitochondrial Damage.PMID 26335776Read ↗

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ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUSSemantic proximity Read ↗

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granulesSemantic proximity Read ↗

The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity.Semantic proximity Read ↗

Expression of human FUS protein in Drosophila leads to progressive neurodegeneration.Semantic proximity Read ↗

Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Widespread Mislocalization of FUS Is Associated With Mitochondrial Abnormalities in Skeletal Muscle in Amyotrophic Lateral Sclerosis With FUS Mutations.Semantic proximity Read ↗

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