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Article

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions.

Oncotarget - 20 Oct 2015

Lee Meng-Horng, Wu Pei-Hsun, Gilkes Daniele, Aifuwa Ivie, Wirtz Denis

Abstract excerpt

Recent work suggests that the dissemination of tumor cells may occur in parallel with, and even preceed, tumor growth. The mechanism for this early invasion is largely unknown. Here, we find that mammary epithelial cells (MECs) induce neighboring breast carcinoma cells (BCCs) to cross the basement membrane by secreting soluble laminin. Laminin continuously produced by MECs induce long membrane cellular...

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Source

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Identifiers

PMID: 26334095
DOI: 10.18632/oncotarget.4728
PMCID: PMC4741718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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