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Article

Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells.

Cancer research - 15 Jul 2008

Whipple Rebecca A, Balzer Eric M, Cho Edward H, Matrone Michael A, Yoon Jennifer R, Martin Stuart S

Abstract excerpt

Solid tumor metastasis often involves detachment of epithelial carcinoma cells into the vasculature or lymphatics. However, most studies of cytoskeletal rearrangement in solid tumors focus on attached cells. In this study, we report for the first time that human breast tumor cells produce unique tubulin-based protrusions when detached from extracellular matrix. Tumor cell lines of high metastatic potential show...

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Share to Cell Adhesion
Share to Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasm Metastasis

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Source

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Identifiers

PMID: 18632620
DOI: 10.1158/0008-5472.CAN-07-6589
PMCID: PMC2859318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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