Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.

doi:10.1212/WNL.0000000000001946

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Article

Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.

Neurology - 10 Nov 2015

Labbé Catherine, Ogaki Kotaro, Lorenzo-Betancor Oswaldo, Soto-Ortolaza Alexandra I, Walton Ronald L, Rayaprolu Sruti, Fujioka Shinsuke, Murray Melissa E, Heckman Michael G, Puschmann Andreas, McCarthy Allan, Lynch Timothy, Siuda Joanna, Opala Grzegorz, Rudzinska Monika, Krygowska-Wajs Anna, Barcikowska Maria, Czyzewski Krzysztof, Sanotsky Yanosh, Rektorová Irena, McLean Pamela J, Rademakers Rosa, Ertekin-Taner Nilüfer, Hassan Anhar, Ahlskog J Eric, Boeve Bradley F, Petersen Ronald C, Maraganore Demetrius M, Adler Charles H, Ferman Tanis J, Parisi Joseph E, Graff-Radford Neill R, Uitti Ryan J, Wszolek Zbigniew K, Dickson Dennis W, Ross Owen A

Abstract excerpt

OBJECTIVE: To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. METHODS: In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 with clinical dementia with Lewy bodies (DLB), 181 with multiple system atrophy (MSA), 832 with...

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Identifiers

PMID: 26333800
DOI: 10.1212/WNL.0000000000001946
PMCID: PMC4653108

Genes

MAF
MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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