Article
Genetic polymorphisms of UGT1A6 in a Japanese population.
Drug metabolism and pharmacokinetics - 1 Feb 2005
Saeki Mayumi, Saito Yoshiro, Jinno Hideto, Sai Kimie, Kaniwa Nahoko, Ozawa Shogo, Komamura Kazuo, Kotake Takeshi, Morishita Hideki, Kamakura Shiro, Kitakaze Masafumi, Tomoike Hitonobu, Shirao Kuniaki, Minami Hironobu, Ohtsu Atsushi, Yoshida Teruhiko, Saijo Nagahiro, Kamatani Naoyuki, Sawada Jun-ichi
Abstract excerpt
Thirteen single nucleotide polymorphisms (SNPs), including 6 novel ones, were found in exon 1 and its flanking region of UDP-glucuronosyltransferase (UGT) 1A6 from 195 Japanese subjects. Several novel SNPs were identified, including 269G>A (R90H), 279A>G (S93S), and 308C>A (S103X) in exon 1, and IVS1+109C>T, IVS1+120A>G, and IVS1+142C>T in the intron downstream of exon 1. Among these SNPs, 308C>A confers...
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