Article
Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation.
Annals of neurology - 1 May 2007
Kauwe John S K, Jacquart Sarah, Chakraverty Sumi, Wang Jun, Mayo Kevin, Fagan Anne M, Holtzman David M, Morris John C, Goate Alison M
Abstract excerpt
OBJECTIVE: Aggregation and deposition of amyloid beta (Abeta) in the brain is thought to be central to the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that cerebrospinal fluid (CSF) Abeta levels are strongly correlated with AD status and progression, and may be a meaningful endophenotype for AD. Mutations in presenilin 1 (PSEN1) are known to cause AD and change Abeta levels. In this study, we...
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