Article
Effect of a functional polymorphism in the pre-miR-146a gene on the risk and prognosis of renal cell carcinoma.
Molecular medicine reports - 1 Nov 2015
Huang Zhilong, Lu Zhanpeng, Tian Jingchang, Wang Guangjian, Gao Zhenli
Abstract excerpt
MicroRNAs (miRNAs) are non-coding RNAs that function as regulators of tumor suppressors and oncogenes. A G>C polymorphism (rs2910164) in the miR‑146a precursor sequence leads to a functional change associated with a risk for various types of malignancy. The role of this single nucleotide polymorphism in the pathogenesis of renal cell carcinoma (RCC) has not yet been examined. The present study evaluated the...
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