Article
A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population.
Archives of toxicology - 1 May 2013
Ma Lan, Zhu Lingjun, Gu Dongying, Chu Haiyan, Tong Na, Chen Jinfei, Zhang Zhengdong, Wang Meilin
Abstract excerpt
MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigated whether rs2910164 is associated with the risk of colorectal cancer (CRC) in a Chinese...
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