Article
A common polymorphism in pre-microRNA-146a is associated with lung cancer risk in a Korean population.
Gene - 15 Jan 2014
Jeon Hyo-Sung, Lee Yong Hoon, Lee Shin Yup, Jang Ji-Ae, Choi Yi-Young, Yoo Seung Soo, Lee Won Kee, Choi Jin Eun, Son Ji Woong, Kang Young Mo, Park Jae Yong
Abstract excerpt
INTRODUCTION: MicroRNAs (miRs) play important roles in the development and progression of human cancers. MiR-146a down-regulates epidermal growth factor receptor and the nuclear factor-κB regulatory kinase interleukin-1 receptor-associated kinase 1 genes that play important roles in lung carcinogenesis. This study was conducted to evaluate the association between rs2910164C>G, a functional polymorphism in the...
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