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Article

Quantitative system drift.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2026

Veller Carl, Muralidhar Pavitra

Abstract excerpt

We consider a biological system composed of multiple genetically variable components, the combined result of which is a quantitative trait under stabilizing selection for an optimal value. We show mathematically that, while the mean value of the system is ultimately constrained to remain near its optimum, the mean contributions of individual components are free to drift far from their initial values. Each...

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Identifiers

PMID: 41860967
DOI: 10.1073/pnas.2527137123
PMCID: PMC13012032

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