Article
Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers.
Laboratory investigation; a journal of technical methods and pathology - 1 Aug 2009
Kang Hyun Ju, Lee Hanna, Choi Hee-Jung, Youn Ju Ho, Shin Jeon-Soo, Ahn Yeong Hee, Yoo Jong Shin, Paik Young-Ki, Kim Hoguen
Abstract excerpt
The high mobility group box 1 (HMGB1) protein, a non-histone nuclear factor, is overexpressed and localizes to the cytoplasm in some cancer cells. However, the mechanism of cytoplasmic HMGB1 transport, extracellular secretion, and its role in cancer progression is not clear. To simulate the activ...
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