Article
The subcellular distribution of phosphorylated Y-box-binding protein-1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features.
Molecular oncology - 1 Oct 2025
Lettau Konstanze, Forchhammer Stephan, Fehrenbacher Birgit, Mahmutovic Lejla, Scharpf Marcus, Blumenstock Gunnar, Schaller Martin, Bonzheim Irina, Khozooei Shayan, Toulany Mahmoud
Abstract excerpt
Oncoprotein Y-box-binding protein-1 (YB-1) is involved in all cancer hallmarks. One of the most studied post-translational modifications of YB-1 is phosphorylation on Serine 102 (S102), which is involved in cancer progression. KRAS mutations are frequent, have been associated with poor prognosis and therapy resistance, and they are considered a major stimulator of S102 YB-1 in vitro. In this study, a relationship...
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