Article
Identification of the Ligand Binding Site for the Integrin α9β1 in the Third Fibronectin Type III Repeat of Tenascin-C
1 May 1998
Abstract excerpt
The integrin alpha9 subunit forms a single heterodimer, alpha9 beta1 that mediates cell adhesion to a site within the third fibronectin type III repeat of tenascin-C (TNfn3). In contrast to at least 3 other integrins that bind to this region of tenascin-C, alpha9 beta1 does not recognize the common integrin recognition motif, Arg-Gly-Asp (RGD). In this report, we have used substitution mutagenesis to identify a...
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