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Article

Functional analysis of the human orthologue of the RSP5-encoded ubiquitin protein ligase, hNedd4, in yeast.

Current genetics - 1 Apr 2003

Gajewska Beata, Shcherbik Natalia, Oficjalska Danuta, Haines Dale S, Zoładek Teresa

Abstract excerpt

hNedd4 and Rsp5p are orthologous ubiquitin ligases that contain a catalytic Hect domain, a C2 domain and multiple WW domains that mediate interactions with proteins. hNedd4 associates with the epithelial sodium channel and mutations disrupting this interaction lead to Liddle's syndrome, a heritable hypertension. Yeast Rsp5p ubiquitinates plasma membrane receptors and transporters and regulates their endocytosis....

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PMID: 12684839
DOI: 10.1007/s00294-003-0371-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional analysis of the human orthologue of the RSP5-encoded ubiquitin protein ligase, hNedd4, in yeast.PMID 12684839Read ↗

Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis.Semantic proximity Read ↗

Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway.Semantic proximity Read ↗

Functional domains of the Rsp5 ubiquitin-protein ligase.Semantic proximity Read ↗

Substrate proteolysis is inhibited by dominant-negative Nedd4 and Rsp5 mutants harboring alterations in WW domain 1.Semantic proximity Read ↗

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo.Semantic proximity Read ↗

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins.Semantic proximity Read ↗

Hem12, an enzyme of heme biosynthesis pathway, is monoubiquitinated by Rsp5 ubiquitin ligase in yeast cells.Semantic proximity Read ↗

A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel.Semantic proximity Read ↗

Rsp5 is required for the nuclear export of mRNA of HSF1 and MSN2/4 under stress conditions in Saccharomyces cerevisiae.Semantic proximity Read ↗

WW domains of Rsp5p define different functions: determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.Semantic proximity Read ↗

Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.Semantic proximity Read ↗

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