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Article

HBx triggers either cellular senescence or cell proliferation depending on cellular phenotype.

Journal of viral hepatitis - 1 Feb 2016

Idrissi M E, Hachem H, Koering C, Merle P, Thénoz M, Mortreux F, Wattel E

Abstract excerpt

Replicative senescence is a hallmark of chronic liver diseases including chronic hepatitis B virus (HBV) infection, whereas HBV-encoded oncoproteins HBx and preS2 have been found to overcome senescence. HBx possesses a C-terminal truncation mainly in hepatocellular carcinomas but also in noncance...

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Identifiers

PMID: 26316075
DOI: 10.1111/jvh.12450

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26316075-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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