Article
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2016
Abdelmaksoud-Dammak Rania, Saadallah-Kallel Amena, Miladi-Abdennadher Imen, Ayedi Lobna, Khabir Abdelmajid, Sallemi-Boudawara Tahia, Frikha Mounir, Daoud Jamel, Mokdad-Gargouri Raja
Abstract excerpt
The ubiquitin-proteasome system plays an essential regulatory role in various cellular processes. Besides its involvement in normal cellular functions, the alteration of proteasomal activity contributes to the pathological states of several clinical disorders, including cancer. Aberrant methylati...
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