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Article

Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.

International journal of molecular sciences - 30 May 2020

Sharma Amit, Liu Hongde, Tobar-Tosse Fabian, Chand Dakal Tikam, Ludwig Michael, Holz Frank G, Loeffler Karin U, Wüllner Ullrich, Herwig-Carl Martina C

Abstract excerpt

Emerging evidence suggests an inverse association between cancer and neurodegenerative diseases (NDD). Although phenotypically different, both diseases display a significant imbalance in the ubiquitination/deubiquitination processes. Therefore, we particularly investigated the expression of ubiquitin C-terminal hydrolases (UCHs: UCH-L1, UCH-L3, UCH-L5 and BAP1), a subfamily of deubiquitinating enzymes (DUBs),...

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Identifiers

PMID: 32486284
DOI: 10.3390/ijms21113910
PMCID: PMC7312489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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