Article

Integrating Human Genetics and Protective Genome Editing to Enable ADGRE2-Directed AML Therapy

2025-08-22

Abstract excerpt

<h4>ABSTRACT</h4> Acute myeloid leukemia (AML) remains a major therapeutic challenge due to extensive disease heterogeneity and lack of cancer-specific antigens. ADGRE2 has emerged as a promising AML target with broad expression in AML patient blast and leukemic stem cell-enriched populations. However, comparable expression in healthy hematopoietic stem and progenitor cells (HSPCs) and myeloid lineages suggests a...

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Literature Corpus work: 8a8dbc4b-decf-512b-b8bd-99e1315777ac
DOI: 10.1101/2025.08.21.671614

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