Article
Sex-Specific Cortical Brain Differences in Children at Familial High Risk for Schizophrenia or Bipolar Disorder.
Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 May 2026
Madsen Kathrine Skak, Baaré William F C, Hernandez-Torres Enedino, Larsen Kit Melissa, Kaminski Adam, Johnsen Line Korsgaard, Hemager Nicoline, Gregersen Maja, Brandt Julie Marie, Krantz Mette Falkenberg, Weye Nanna, Søndergaard Anne, Greve Aja Neergaard, Knudsen Christina Bruun, Andreassen Anna Krogh, Veddum Lotte, Lund Torben E, Mors Ole, Thorup Anne Amalie Elgaard, Østergaard Leif, Nordentoft Merete, Siebner Hartwig R
Abstract excerpt
BACKGROUND: Familial high risk (FHR) is the strongest predictor of developing schizophrenia (SZ) and bipolar disorder (BP). Children at FHR uniquely allow for the identification of early brain markers of vulnerability. Previous studies have often spanned wide age ranges and neglected sex differences, despite evidence of distinct sex-specific brain developmental trajectories. We investigated sex-specific group...
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