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Article

Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease.

Diabetes - 1 Dec 2015

Todd Jennifer N, Dahlström Emma H, Salem Rany M, Sandholm Niina, Forsblom Carol, McKnight Amy J, Maxwell Alexander P, Brennan Eoin, Sadlier Denise, Godson Catherine, Groop Per-Henrik, Hirschhorn Joel N, Florez Jose C

Abstract excerpt

Obesity has been posited as an independent risk factor for diabetic kidney disease (DKD), but establishing causality from observational data is problematic. We aimed to test whether obesity is causally related to DKD using Mendelian randomization, which exploits the random assortment of genes during meiosis. In 6,049 subjects with type 1 diabetes, we used a weighted genetic risk score (GRS) comprised of 32...

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Identifiers

PMID: 26307587
DOI: 10.2337/db15-0254
PMCID: PMC4657582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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