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Article

Body Mass Index and Risk of Diabetic Nephropathy: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 17 May 2022

Lu Jingru, Liu Xiaoshuang, Jiang Song, Kan Shuyan, An Yu, Zheng Chunxia, Li Xiang, Liu Zhihong, Xie Guotong

Abstract excerpt

CONTEXT: The associations of obesity and diabetic nephropathy (DN) in type 2 diabetes are inconsistent in observational studies, and causality remains unclear. OBJECTIVE: To explore the causal effect of body mass index (BMI) on DN, estimated glomerular filtration rate (eGFR), and proteinuria in type 2 diabetes by a 2-sample Mendelian randomization (MR) analysis. METHODS: A total of 56 genetic variants were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35191949
DOI: 10.1210/clinem/dgac057

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