Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic assessment of obesity-related risk factors in renal cancer etiology: A longitudinal risk and Mendelian randomization analysis.

PLoS medicine - 1 Feb 2026

Alcala Karine, Mariosa Daniela, Jacobson Sara, Coscia-Requena Claudia, Dimou Niki, Franklin Oskar, Martin Richard M, Smith George Davey, Gunter Marc J, Brennan Paul, Pollak Michael, Langdon Ryan, Johansson Mattias

Abstract excerpt

BACKGROUND: Excess body adiposity is an established cause of renal cancer, but underlying molecular pathways mediating this relationship remain unclear. This study aimed to systematically evaluate a panel of obesity-related risk factors as potential mediators in renal cancer etiology. METHODS AND FINDINGS: We used two complementary approaches to evaluate obesity-related risk factors in renal cancer etiology: (i)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longitudinal Studies

Share to Mendelian Randomization Analysis

Share to Obesity

Share to Proportional Hazards Models

Share to Sweden

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 41666231
DOI: 10.1371/journal.pmed.1004906
PMCID: PMC12919923

Genes

DBP
SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic assessment of obesity-related risk factors in renal cancer etiology: A longitudinal risk and Mendelian randomization analysis.PMID 41666231Read ↗

The influence of obesity-related factors in the etiology of renal cell carcinoma—A mendelian randomization studySemantic proximity Read ↗

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomicsSemantic proximity Read ↗

Obesity as a cause of kidney disease – insights from Mendelian randomisation studiesSemantic proximity Read ↗

Causality of visceral adipose tissue on chronic kidney disease and renal function measure indicators, and mediation role of hypertension: Mendelian randomization studySemantic proximity Read ↗

Obesity and Kidney Function: A Two-Sample Mendelian Randomization StudySemantic proximity Read ↗

Blood Lipid Metabolic Profiles and Causal Links to Site-Specific Cancer Risks: A Mendelian Randomization Study.Semantic proximity Read ↗

Body fatness associations with cancer: evidence from recent epidemiological studies and future directionsSemantic proximity Read ↗

Causal Effects of Life Course Adiposity on Chronic Kidney Disease: A Mendelian Randomization StudySemantic proximity Read ↗

Higher genetically predicted low-density lipoprotein levels increase the renal cancer risk independent of triglycerides and high-density lipoprotein levels: A Mendelian randomization study.Semantic proximity Read ↗

Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney diseaseSemantic proximity Read ↗

Exploring the Causal Relationship Between Body Mass Index and Kidney Function Using Tissue-Partitioned Mendelian RandomizationSemantic proximity Read ↗

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.