Article
Tailored selection of study individuals to be sequenced in order to improve the accuracy of genotype imputation.
Genetic epidemiology - 1 Feb 2015
Peil Barbara, Kabisch Maria, Fischer Christine, Hamann Ute, Bermejo Justo Lorenzo
Abstract excerpt
The addition of sequence data from own-study individuals to genotypes from external data repositories, for example, the HapMap, has been shown to improve the accuracy of imputed genotypes. Early approaches for reference panel selection favored individuals who best reflect recombination patterns i...
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